Asymmetric Mach–Zehnder Interferometer Based Biosensors for Aflatoxin M1 Detection
oleh: Tatevik Chalyan, Romain Guider, Laura Pasquardini, Manuela Zanetti, Floris Falke, Erik Schreuder, Rene G. Heideman, Cecilia Pederzolli, Lorenzo Pavesi
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2016-01-01 |
Deskripsi
In this work, we present a study of Aflatoxin M1 detection by photonic biosensors based on Si3N4 Asymmetric Mach–Zehnder Interferometer (aMZI) functionalized with antibodies fragments (Fab′). We measured a best volumetric sensitivity of 104 rad/RIU, leading to a Limit of Detection below 5 × 10−7 RIU. On sensors functionalized with Fab′, we performed specific and non-specific sensing measurements at various toxin concentrations. Reproducibility of the measurements and re-usability of the sensor were also investigated.