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Hydroxyapatite (HA) has been widely used in biomedical applications. HA is prepared from natural sources of eggshell. The obtained HA is composited with TiO₂ using the hydrothermal method at a temperature of 230 °C. The structure and morphology of HA-TiO₂ composites are characterized by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and a scanning electron microscope (SEM). Meanwhile, its antibacterial activity was tested on <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> bacteria. The formation of the HA-TiO₂ composite is evidenced by typical peaks on the XRD pattern for HA and TiO₂. The FTIR spectrum shows that no bond formed between TiO₂ and HA which indicates the formation of composites. The smallest crystallite size and the highest specific surface area were obtained from the composite with the composition of HA-TiO₂ 30:70. In addition, the composition of the composite also shows the smallest particle size distribution. Therefore, the presence of TiO₂ plays a significant role in determining the HA properties formed. Furthermore, the HA-TiO₂ composite showed good antibacterial activity using disk diffusion and optical density (OD) methods. These results indicate that the synergistic combination of HA from eggshell with TiO₂ has favorable properties for antibacterial activity.