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OBJECTIVE: The combined action of two or more chemotherapeutic agents and/or biological agents can be quantitatively described wilh empirical multidimensional concenlration-effect response surface models. This intuitive statistical approach provides a framework for suggesting experimental designs for in vitro. in vivo and possibly clinical experiments of agent combinations. Five rival 32-point experimental designs for in vitro continuous response two-agent combined action studies were compared using Monte Carlo simulation.