Error correction enables use of Oxford Nanopore technology for reference-free transcriptome analysis
oleh: Kristoffer Sahlin, Botond Sipos, Phillip L. James, Paul Medvedev
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-01-01 |
Deskripsi
Nanopore sequencing technologies applied to transcriptome analysis suffer from high error rates, limiting them largely to reference-based analyses. Here, the authors develop a computational error correction method for transcriptome analysis that reduces the median error rate from ~7% to ~1%.