Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue
oleh: Mithun Sinha, Chandan K. Sen, Kanhaiya Singh, Amitava Das, Subhadip Ghatak, Brian Rhea, Britani Blackstone, Heather M. Powell, Savita Khanna, Sashwati Roy
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-03-01 |
Deskripsi
At the site of injury, macrophages exit their characteristic phenotype undergoing direct conversion to fibroblasts. Keratinocyte-derived miR-21, packaged in extracellular vesicles, enables such plasticity which accounts for the vast majority of all fibroblasts in the granulation tissue.