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Accurately simulating the nonlinear response of reinforced concrete (RC) columns under cyclic loading is crucial in performance-based seismic design for building structures, especially regarding strength degradation. This paper presents the description, calibration and simulation of the hysteretic model for RC columns based on effective hysteretic energy dissipation with positive and negative directions. During the analysis of previous experimental data, the relationship between hysteresis energy dissipation, maximum displacement, and the effects of positive and negative loading directions on strength degradation has been summarized. The proposed method for determining the yield strength of the hysteresis loop is based on the farthest point method. Calibration of the hysteretic models’ existing RC columns’ experimental data demonstrates that the proposed model can simulate the main characteristics that influence deterioration.