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ABSTRACTObjective: To evaluate therole of combination therapy of platelet rich plasma (PRP) with arthrocentesisandtocompareitwith arthrocentesisalonein the temporomandibular dysfuction(TMD)patients.Study Design:Quasiexperimental study.Place and Duration of Study:Oral and Maxillofacial Surgery department, ArmedForcesInstitute ofDentistry, Combined Military HospitalRawalpindi,from Jan2017 to Jun2019. Methodology:Forty-twopatientsdiagnosed withrefractoryunilateral temporomandibular dysfuction,were included in the study. Patients were divided in twogroupswith 21 temporomandibular joints in each. Arthrocentesis alone was thecontrol group (group I) and arthrocentesis with intra-articular injectionofplatelet rich plasma (group II) was thestudygroup. Treat-mentoutcomes were assessed and compared for all patients based on clinical parametersofpre and post treatment; for pain, maximal mouthopening and temporomandibular joint clickingsounds.Results:Out of 42 patients,33(79%)were females and 9(21%)were males with mean age of 34.3 ± 8.4 years.There was statis-tically significant differencein both groupsfor all variables. The p-value of maximum mouth openingof both groups before and after treatment was 0.746and 0.01, jointclickingsounds werepresent in 69% of our patients before the treament and it reduced to 14% after the treatment.There wasmarkedgradualdecreasein pain of bothgroups, group I (6.48 ± 1.470 to 1.81 ± 0.602) and group II (7.29 ± 1.007 to 1.19 ± 0.402).Conclusion:Combination therapy of platelet rich plasma with arthrocentesis is more effective treatment method than arthrocentesis aloneforchronic temporomandibular dysfuctions.