Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity
oleh: A. Rouf Banday, Olusegun O. Onabajo, Seraph Han-Yin Lin, Adeola Obajemu, Joselin M. Vargas, Krista A. Delviks-Frankenberry, Philippe Lamy, Ariunaa Bayanjargal, Clara Zettelmeyer, Oscar Florez-Vargas, Vinay K. Pathak, Lars Dyrskjøt, Ludmila Prokunina-Olsson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-03-01 |
Deskripsi
A. Rouf Banday et al. report targeting alternative splicing of APOBEC3B as a strategy to modulate APOBEC-mediated mutagenesis in cancers. Higher expression of the mutagenic APOBEC3B isoform predicted shorter progression-free survival in bladder cancer patients. Expression of this mutagenic isoform could be decreased by inducing skipping of APOBEC3B exon 5 in cells treated with SF3B1 inhibitor or splice-switching oligos.