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<i>Helicteres hirsuta</i> Lour. is a traditional Vietnamese medicine for treating chronic liver diseases such as cirrhosis and liver cancer. Many in vitro and in vivo experiments have demonstrated that the extracts and isolated compounds from <i>H. hirsuta</i> have diverse pharmacological activities, including antioxidant, anti-inflammatory, and anti-cancer effects. However, the hepatoprotective effects have not been reported until now. Therefore, the methanolic and ethanolic extracts of the aerial part of the <i>H. hirsuta</i> L. (HHM and HHE-1/1) were examined on liver fibrosis induced by carbon tetrachloride (CCl₄) in rats for the first time. The results revealed that all the livers of the model group had stage F4 cirrhosis; the group that received silymarin, and HHM and HHE-1/1 had milder liver damage cirrhosis stage F1-F2 which implies that the methanolic and ethanolic extracts of <i>H. hirsute</i> have a definite advantage in the development of food or oral medications for hepatoprotective activity.