Impaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car?
oleh: Mariana Faria-Urbina, Rudolf K.F. Oliveira, Sergio A. Segrera, Laurie Lawler, Aaron B. Waxman, David M. Systrom
| Format: | Article |
|---|---|
| Diterbitkan: | Wiley 2018-01-01 |
Deskripsi
Ambrisentan in 22 patients with pulmonary hypertension diagnosed during exercise (ePH) improved pulmonary hemodynamics; however, there was only a trend toward increased maximum oxygen uptake (VO 2 max) secondary to decreased maximum exercise systemic oxygen extraction (Ca-vO 2 ). We speculate that improved pulmonary hemodynamics at maximum exercise “unmasked” a pre-existing skeletal muscle abnormality.