AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis
oleh: Hong Jie Zhu, Bo Zhang, Wanqing Wei, Shuang He Liu, Lang Xiang, Jiapeng Zhu, Rui Hua Jiao, Yasuhiro Igarashi, Ghader Bashiri, Yong Liang, Ren Xiang Tan, Hui Ming Ge
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-08-01 |
Deskripsi
Macrocyclization is an important process in bioactive natural product synthesis. Here, the authors report on the study of a macrocyclic ring constructing enzyme in the biosynthesis of alchivemycin A and using gene deletion, biochemical assays and isotope labelling show the enzyme catalyses tandem dehydration and Michael-type addition.