Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback

oleh: Joaquín Gutiérrez Mena, Sant Kumar, Mustafa Khammash

Format: Article
Diterbitkan: Nature Portfolio 2022-08-01

Deskripsi

Communities of microbes play important roles in natural environments and hold great potential for deploying division-of-labor strategies in synthetic biology and bioproduction. Here, in a community of two competing E. coli strains, the authors show that the relative abundances of the strains can be stabilized and steered dynamically with remarkable precision by coupling the cells to an automated computer-controlled feedback-loop.