A molecular atlas of innate immunity to adjuvanted and live attenuated vaccines, in mice
oleh: Audrey Lee, Madeleine K. D. Scott, Florian Wimmers, Prabhu S. Arunachalam, Wei Luo, Christopher B. Fox, Mark Tomai, Purvesh Khatri, Bali Pulendran
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-01-01 |
Deskripsi
Adjuvants provide additional impetus for the immune response to vaccination regimens, however their modes of activity and impact on particular compartments of the immune response are currently not well understood. Here the authors perform high resolution assessment of the immune response to a well-established vaccination model and show innate immune transcriptomic and epigenomic alterations of innate cells in the lymph nodes following vaccination.