The Role of Aldosterone in OSA and OSA-Related Hypertension
oleh: Yi Wang, Yi Wang, Yi Wang, Chuan Xiang Li, Chuan Xiang Li, Chuan Xiang Li, Chuan Xiang Li, Ying Ni Lin, Ying Ni Lin, Ying Ni Lin, Li Yue Zhang, Li Yue Zhang, Li Yue Zhang, Shi Qi Li, Shi Qi Li, Shi Qi Li, Liu Zhang, Liu Zhang, Liu Zhang, Ya Ru Yan, Ya Ru Yan, Ya Ru Yan, Fang Ying Lu, Fang Ying Lu, Fang Ying Lu, Ning Li, Ning Li, Ning Li, Qing Yun Li, Qing Yun Li, Qing Yun Li
| Format: | Article |
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| Diterbitkan: | Frontiers Media S.A. 2022-01-01 |
Deskripsi
Obstructive sleep apnea (OSA) is regarded as an independent risk factor for hypertension. The possible mechanism includes oxidative stress, endothelial injury, sympathetic excitement, renin–angiotensin–aldosterone system activation, etc. Clinical studies have found that there is a high coexistence of OSA and primary aldosteronism in patients with hypertension and that elevated aldosterone levels are independently associated with OSA severity in resistant hypertension. The underlying mechanism is that aldosterone excess can exacerbate OSA through increasing overnight fluid shift and affecting the mass and function of upper airway muscles during the sleep period. Thus, a bidirectional influence between OSA and aldosterone exists and contributes to hypertension in OSA patients, especially resistant hypertension.