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Natural products and chemical analogues are widely used in drug discovery, notably in cancer and infectious disease pharmacotherapy. <i>Sarcophyton convolutum</i> (Alcyoniidae) a Red Sea–derived soft coral has been shown to be a rich source of macrocyclic diterpenes and cyclized derivatives. Two previously undescribed polyoxygenated cembrane-type diterpenoids, sarcoconvolutums F (<b>1</b>) and G (<b>2</b>), as well as four identified analogues (<b>3</b>–<b>6</b>) together with a furan derivate (<b>7</b>) were isolated from a solvent extract. Compounds were identified by spectroscopic techniques, including NMR, HREIMS, and CD, together with close spectral comparisons of previously published data. Sarcoconvolutum F (<b>1</b>) contains a rare 1-peroxid-15-hydroxy-10-ene functionality. Isolated metabolites (<b>1</b>–<b>7</b>) were screened against lung adenocarcinoma (A549), cervical cancer (HeLa) and oral cavity carcinoma (HSC-2) lines. Compound <b>4</b> exhibited an IC₅₀ 56 µM and 55 µM against A549 and HSC-2 cells, respectively.