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Video-assisted thoracoscopic surgery (VATS) segmentectomy is an optimal treatment for malignant pulmonary ground glass nodules (GGNs). However, this surgery is complicated when tumors are located between more than two adjacent segments, although combined subsegmentectomy ensures sufficient margin under uniportal approach. Lobectomy might be inevitable, especially when resecting deep nodules in the central left upper lung lobe. Here, we present cases wherein we performed uniportal VATS (UVATS) resection for GGNs located between borders of left S3 and S4, with three-dimensional reconstruction conducted before surgery. The strategy of resecting central tumors in the left upper lung lobe between left S3 and S4 via UVATS is simple and feasible.