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Objective To explore the applicable conditions and clinical effects of preoperative external carotid artery ligation (LCE) in lateral sphenoid ridge meningiomas (SRM). Methods Thirty⁃two patients with SRM were divided into LCE group (n = 14) and non⁃LCE group (n = 18). Differences were observed between the two groups. Results The average variables of LCE group were less than non⁃LCE group. In LCE group and non⁃LCE group, the blood loss volume was (471.00 ± 182.00) ml and (994.00 ± 278.00) ml respectively, total removal rate was 100.00% and 72.22% respectively, and the surgical time was (5.60 ± 1.40) h and (8.10 ± 1.70) h respectively. The postoperative complication rate of LCE group (1/14, 7.14%) was significantly less than non⁃LCE group (7/18, 38.89%; P = 0.047). Conclusion For large and huge tumors of the lateral SRM, preoperative LCE can significantly reduce intraoperative bleeding and surgical time, simultaneously improve the operation security and the total removal rate. DOI：10.3969/j.issn.1672⁃6731.2012.04.021