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While numerous studies have explored the participatory benefits of social media use for political participation, the empirical literature on the mobilizing role of political memes is nearly absent. In addition, most of the attention has been on Western democratic contexts. By employing survey data from an Asian context—Singapore—this study scrutinizes the impact of exposure to political memes in the interplay between political use of social media and online political participation. In addition, it investigates the contingent role of political cynicism. First, the results show that political social media use is associated with online political participation and that association is mediated by exposure to political memes. Further, moderation analyses indicate that social media use provides participatory gains only for individuals exhibiting low political cynicism. However, when such social media use facilitates exposure to political memes, it primarily mobilizes those with high political cynicism into active online political participation. The results suggest that memes can mobilize disengaged groups into active participation.