Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits
oleh: Julia Böhme, Nuria Martinez, Shamin Li, Andrea Lee, Mardiana Marzuki, Anteneh Mehari Tizazu, David Ackart, Jessica Haugen Frenkel, Alexandra Todd, Ekta Lachmandas, Josephine Lum, Foo Shihui, Tze Pin Ng, Bernett Lee, Anis Larbi, Mihai G. Netea, Randall Basaraba, Reinout van Crevel, Evan Newell, Hardy Kornfeld, Amit Singhal
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-10-01 |
Deskripsi
Metformin is an anti-diabetic drug that has shown promise to reduce M. tuberculosis susceptibility. Here the authors show that this effect is a result of metformin-mediated activation of anti-mycobacterial memory-like antigen-inexperienced CD8+CXCR3+ T cells, an effect that also boosts response to BCG vaccination.