Single-cell replication profiling to measure stochastic variation in mammalian replication timing
oleh: Vishnu Dileep, David M. Gilbert
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-01-01 |
Deskripsi
While DNA replication is temporally regulated during S-phase, variation in replication timing is not well understood. Here, the authors measure variation in replication timing using DNA copy number in single mouse ESCs and find stochastic variation to be independent of elements that regulate timing.