Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration
oleh: Cédric Plutoni, Sarah Keil, Carlos Zeledon, Lara Elis Alberici Delsin, Barbara Decelle, Philippe P. Roux, Sébastien Carréno, Gregory Emery
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-09-01 |
Deskripsi
Directed motility of cell clusters requires coordination of protrusion formation at the front of leader cells and contractility at the rear. Here the authors show that the kinase Misshapen restricts protrusions to the leader cell and promotes contractile forces at the rear of the cluster.