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Coronavirus disease 2019 (COVID-19) prevalence has caused many problems in society and disrupted manyregular aspects of life. COVID-19 contains major structural proteins that among them, S protein can promotefusion of the viral and cellular membranes and facilitate the entry of coronavirus into the host cells. Basigin(BSG) is one of the most important receptors for COVID-19 that mediates its entry to host cells. Also, Basiginhas an important role in male and female reproduction. Basigin is expressed in the uterus and plays animportant role during embryo implantation and needed for successful implantation. Therefore, disruption orinhibition of Basigin causes to a weakness in embryo implantation. Therefore, if a woman or a man is infectedwith COVID-19, it is recommended that they do not attempt to conception until their treatment is complete. Itis also recommended tests for COVID-19 be performed on infertile couples before using assisted reproductivetechnology (ART).