Essential roles of plexin-B3+ oligodendrocyte precursor cells in the pathogenesis of Alzheimer’s disease
oleh: Naomi Nihonmatsu-Kikuchi, Xiu-Jun Yu, Yoshiki Matsuda, Nobuyuki Ozawa, Taeko Ito, Kazuhito Satou, Tadashi Kaname, Yasushi Iwasaki, Akio Akagi, Mari Yoshida, Shuta Toru, Katsuiku Hirokawa, Akihiko Takashima, Masato Hasegawa, Toshiki Uchihara, Yoshitaka Tatebayashi
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2021-07-01 |
Deskripsi
In order to investigate the role of oligodendrocyte lineage cells in Alzheimer’s Disease (AD) pathology, Nihonmatsu-Kikuchi et al developed a culture method for adult oligodendrocyte progenitor cells in the rat. Using this method as well as imaging AD patient brain tissue, they found that plexin-B3-expressing cells could be a potential source of amyloid β peptide.