Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions
oleh: Pranam Chatterjee, Manvitha Ponnapati, Christian Kramme, Alexandru M. Plesa, George M. Church, Joseph M. Jacobson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-11-01 |
Deskripsi
Pranam Chatterjee et al. present a novel computational platform for engineering peptide fusions that bind to the SARS-CoV-2 spike protein and tag it for proteasomal degradation. They experimentally validate an optimal variant in human cells, showing that it inhibits production of infection-competent virus.