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This article investigates the link between <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection and cardiovascular and neurological disorders. Recent research suggests that <i>H. pylori</i> may play a role in cardiovascular diseases like atherosclerosis, myocardial infarction, and stroke, as well as neurological diseases including Alzheimer’s disease, multiple sclerosis, and Parkinson’s disease. Cardiovascular Diseases: <i>H. pylori</i> induces endothelial dysfunction and chronic inflammation, promoting atherosclerotic plaque formation and other cardiac complications. High infection prevalence in cardiovascular patients implies that systemic inflammation from <i>H. pylori</i> accelerates disease progression. Eradication therapies combined with anti-inflammatory and lipid-lowering treatments may reduce cardiovascular risk. Neurological Diseases: <i>H. pylori</i> may contribute to Alzheimer’s, multiple sclerosis, and Parkinson’s through systemic inflammation, neuroinflammation, and autoimmune responses. Increased infection prevalence in these patients suggests bacterial involvement in disease pathogenesis. The eradication of <i>H. pylori</i> could reduce neuroinflammation and improve outcomes. Discussions and Future Research: Managing <i>H. pylori</i> infection in clinical practice could impact public health and treatment approaches. Further research is needed to clarify these relationships. Longitudinal and mechanistic studies are essential to fully understand <i>H. pylori</i>’s role in these conditions. Conclusions: <i>H. pylori</i> infection is a potential risk factor for various cardiovascular and neurological conditions. Additional research is critical for developing effective prevention and treatment strategies. Targeted therapies, including <i>H. pylori</i> eradication combined with anti-inflammatory treatments, could improve clinical outcomes. These findings highlight the need for an integrated clinical approach to include <i>H. pylori</i> evaluation and treatment.