The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation
oleh: Chih-Yuan Lee, Ting-Yu Lai, Meng-Kun Tsai, Yung-Chi Chang, Yu-Hsin Ho, I-Shing Yu, Tzu-Wen Yeh, Chih-Chang Chou, You-Sheng Lin, Toby Lawrence, Li-Chung Hsu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-06-01 |
Deskripsi
Caveolae and their major constituent Caveolin-1 (CAV1) play an important role in signalling pathways involved in inflammation, but regulators of CAV1 protein stability are unknown. Here, the authors show that E3 ubiquitin ligase ZNRF1 induces degradation of CAV1 in response to TLR4 activation, and mediates the pro-inflammatory response bothin vitro and in vivo.