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<p>Background. Macrolide-resistant strains of betahemolytic streptococci have been isolated in Pomurje region in Slovenia. The aim of the study was to determine phenotypes of macrolide-lincozamide resistance and patterns of resistance to selected antibiotics in these isolates.</p><p>Methods. Twenty-one erythromycin-resistant isolates from group B and group G beta-hemolytic streptococci, obtained from patients in Pomurje were analyzed. Phenotypes of macrolide-lincozamide resistance were determined in all isolates. In group B and group G streptococci susceptibility to 8 and 14 antibiotics was tested, respectively.</p><p>Results. All 42 isolates were susceptible to penicillin and vancomycin. The majority of erythromycin-resistant group B streptococci isolates was tetracycline-resistant but susceptible to chloramphenicol and ofloxacin. In erythromycin-resistant isolates of group G streptococci 5 different resistance patterns were found. The most frequent pattern was a resistance to multiple antibiotics (besides erythromycin also to midekamycin, clindamycin, tetracycline, chloramphenicol and several fluoroquinolones).</p><p>Conclusions. These resistant isolates are unique and represent novel example of a strong bacterial ability to adapt to changes in their environment and consequently survive in the presence of antibiotics.<br /><br /></p>