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<h2>Background: Nowadays, nosocomial infection with multidrug-resistant Acinetobacter is an important problem in the world, which is facing wide spectrum antibiotics and hence has become resistant.</h2><p><strong>M</strong><strong>aterials and Methods: </strong>In this study, positive cultures of Acinetobacter from one hundred clinical samples in seven hospitals from Tehran during 2012-2013 were collected for checking antibiotic susceptibility. Samples test with Ceftazidim, Cefepime, Amikacine and Imipenem by E-test and for Tazocin, Colistin and Tigecycline was performed with disk diffusion method.</p><p><strong>R</strong><strong>es</strong><strong>ults: </strong>For Colistin 10 samples, and for Tazocin, 40 samples were performed by E-test method. Then <em>boumannii</em> species of bacteria and non-<em>baumannii</em> Acinetobacter were separated by PCR and antibiotic susceptibility testing was performed on them. 89% of Acinetobacter samples were <em>boumannii</em> species, which was isolated from respiratory secretions at ICU.</p><p><strong>C</strong><strong>onclusion: </strong>Boumannii and non-boumannii species of bacteria with a high percentage were resistant to Ceftazidim, Amikacine, Cefepime, Tazocin and Imipenem. All baumannii and non-boumannii Acinetobacter were sensitive to Colistin, were only 75% sensitive to Tigecycline, which is a new glycylcycline. Colistin and Tazocin results in samples limited to the E-test method were similar with disk diffusion.</p>