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Five new lipids, tricholixins A–E (<b>1</b>–<b>5</b>), and two known terpenoids, brasilane A (<b>6</b>) and harzianone A (<b>7</b>), were discovered from a deep-sea strain (R22) of the fungus <i>Trichoderma lixii</i> isolated from the cold seep sediments of the South China Sea. Their structures and relative configurations were identified by meticulous analysis of MS and IR as well as NMR data. The absolute configuration of <b>5</b> was ascertained by dimolybdenum-induced ECD data in particular. Compounds <b>1</b> and <b>2</b> represent the only two new butenolides from marine-derived <i>Trichoderma</i>, and they further add to the structural diversity of these molecules. Although <b>6</b> has been reported from a basidiomycete previously, it is the first brasilane aminoglycoside of <i>Trichoderma</i> origin. During the assay against wheat-pathogenic fungi, both <b>1</b> and <b>2</b> inhibited <i>Fusarium graminearum</i> with an MIC value of 25.0 μg/mL, and <b>6</b> suppressed <i>Gaeumannomyces graminis</i> with an MIC value of 12.5 μg/mL. Moreover, the three isolates also showed low toxicity to the brine shrimp <i>Artemia salina</i>.