Gastrointestinal Cytoprotection by PPARš¯›¾ Ligands
oleh: Yuji Naito, Tomohisa Takagi, Toshikazu Yoshikawa
| Format: | Article |
|---|---|
| Diterbitkan: | Hindawi Limited 2010-01-01 |
Deskripsi
Peroxisome proliferator-activated receptor š¯›¾ (PPARš¯›¾) is a nuclear receptor that is known to play a central role in lipid metabolism and insulin sensitivity as well as inflammation and cell proliferation. According to the results obtained from studies on several animal models of gastrointestinal inflammation, PPARš¯›¾ has been implicated in the regulation of the immune response, particularly inflammation control, and has gained importance as a potential therapeutic target in the management of gastrointestinal inflammation. In the present paper, we present the current knowledge on the role of PPARš¯›¾ ligands in the gastrointestinal tract.