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Extranodal lymphoma rarely presents as a primary tumor in the gastrointestinal tract, particularly in the form of intussusception in adults. We report the case of a 30-year-old woman admitted with intermittent right lower abdominal pain for one month and a palpable mass on physical examination. Computed tomography revealed an ileocolic intussusception with rectal polypoid mass lesions. The patient underwent a right hemicolectomy because the lead point of the intussusception was identified as a terminal ileum polyp. Histopathological examination revealed diffuse large B-cell lymphoma. In the event of an abdominal mass with radiological evidence of colonic intussusception, surgery remains crucial to avoid unnecessary complications.