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<p><strong>Background:</strong> Harmaline‐induced tremor in rodents has been extensively used as an animal model for essential tremor (ET). However, there is no visual documentation in the published literature.</p><p><strong>Methods:</strong> We injected mice subcutaneously with either 20 mg/kg of harmaline hydrochloride or saline and then videotaped the responses.</p><p><strong>Results:</strong> Action and postural tremor in the mouse began 5 minutes after subcutaneous harmaline injection and peaked at approximately 30 minutes. The tremor involved the head, trunk, tail, and four limbs and lasted for approximately 2 hours. The forelimb tremor was postural or action tremor, similar to that observed in ET.</p><p><strong>Discussion:</strong> This video segment provides the first visual documentation of the phenomenology of harmaline‐induced tremor in a mouse. We also raise several unanswered questions regarding the use of harmaline‐induced tremor to model ET.</p>