Correction of Clcn1 alternative splicing reverses muscle fiber type transition in mice with myotonic dystrophy
oleh: Ningyan Hu, Eunjoo Kim, Layal Antoury, Thurman M. Wheeler
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-04-01 |
Deskripsi
In a double homozygous mouse model of myotonic dystrophy type 1, Hu et al. use antisense oligonucleotide correction of myotonia to induce a therapeutic shift from an overabundance of oxidative muscle fibers to mechanically stronger glycolytic fibers.