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<p align="LEFT"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;">Background. </span></span></span><em><span style="color: #231f20; font-family: GaramondItcTEE-LighItal; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-LighItal; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-LighItal; font-size: xx-small;">The soluble interleukin-2 receptor</span></span></span></em></p><em><em></em></em><p align="LEFT">(s-IL-2R) is a soluble cytokine receptor which directly reflects</p><em><em></em></em><p align="LEFT">the levels of the IL-2 receptor on lymphocytes T, which, along</p><em><em></em></em><p align="LEFT">with the IL-2 itself, is important for the specific immune response.</p><em><em></em></em><p align="LEFT"> </p><p align="LEFT">The aim of the study. We attempted to prove diagnostic and</p><em><em></em></em><p align="LEFT">prognostic significance of s-IL-2R in sepsis cases.</p><em></em><p align="LEFT"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;"><br /></span></span></span></p><p align="LEFT"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;">Patients and methods. </span></span></span><em><span style="color: #231f20; font-family: GaramondItcTEE-LighItal; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-LighItal; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-LighItal; font-size: xx-small;">In the period of three years we examined</span></span></span></em></p><em><em></em></em><p align="LEFT">64 healthy blood donors and subjects in systematic health</p><em><em></em></em><p align="LEFT">examinations and examined 50 septic patients with clinical</p><em><em></em></em><p align="LEFT">and laboratory symptoms of sepsis treated in units for the intensive</p><em><em></em></em><p align="LEFT">therapy of adults at the Clinic for Infectious Diseases</p><em><em></em></em><p align="LEFT">and Febrile States at the Clinic Centre of Ljubljana. The assay</p><em><em></em></em><p align="LEFT">for s-IL-2R was performed with a kit from Eurogenetics (Belgium).</p><em></em><p align="LEFT"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;"><br /></span></span></span></p><p align="LEFT"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;">Results. </span></span></span><em><span style="color: #231f20; font-family: GaramondItcTEE-LighItal; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-LighItal; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-LighItal; font-size: xx-small;">We proved that the median concentration of s-IL-2R in</span></span></span></em></p><em><em></em></em><p align="LEFT">septic patients with positive and negative blood culture are</p><em><em></em></em><p align="LEFT">significantly higher than healthy subjects (p &lt; 0.05) and were</p><em><em></em></em><p align="LEFT">also significantly higher in the blood of dead patients than in</p><em><em></em></em><p align="LEFT">the blood of survivors (p &lt; 0.05). The mean concentration of</p><em><em></em></em><p align="LEFT">s-IL-2R did not differ in septic patients with positive blood culture</p><em><em></em></em><p align="LEFT">from those with negative blood culture and did not differ</p><em><em></em></em><p align="LEFT">for gram negative pathogens from those for gram positive pathogens.</p><em><em></em></em><p align="LEFT">Time dynamics showed the increase levels of s-IL-2R</p><em><em></em></em><p align="LEFT">for the first 48 hours.</p><em></em><p align="LEFT"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;"><br /></span></span></span></p><p align="LEFT"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-Ligh; font-size: xx-small;">Conclusions. </span></span></span><em><span style="color: #231f20; font-family: GaramondItcTEE-LighItal; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-LighItal; font-size: xx-small;"><span style="color: #231f20; font-family: GaramondItcTEE-LighItal; font-size: xx-small;">s-IL-2R levels are elevated in adults with sepsis.</span></span></span></em></p><em><em></em></em><p>Elevation of s-IL-2R are significantly associated with death.</p><em></em>