Structural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex
oleh: Anne-Emmanuelle Foucher, Leila Touat-Todeschini, Ariadna B. Juarez-Martinez, Auriane Rakitch, Hamida Laroussi, Claire Karczewski, Samira Acajjaoui, Montserrat Soler-López, Stephen Cusack, Cameron D. Mackereth, André Verdel, Jan Kadlec
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-08-01 |
Deskripsi
Unwanted RNA transcripts are targeted for degradation by nuclear complexes such as MTREC/PAXT. Here, the authors structurally and functionally characterized three interfaces of the scaffold protein Red1, providing mechanistic insights into conserved features of MTREC/PAXT architecture.