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Background: Stroke is the leading cause for premature deaths and disability in India. For more than 30 years, assessing Quality of Life (QoL) has been a significant component in assessing stroke patients and their treatment. QoL is a multidimensional term with at least three major domains–physical, mental, and social. Because stroke may have an adverse effect on many facets of life, its effects on health-related quality of life might be severe. Aim and Objectives: To investigate the impact of stroke on mental status and health-related QoL among survivors in a tertiary care hospital. Material and Methods: An observational study was conducted in a tertiary care hospital in Pune, Maharashtra between November 2020 and November 2021. A total of 76 stroke survivors were interviewed using Stroke Specific-Quality of Life Scale (SS-QOL), Mini Mental State Examination (MMSE) and Modified Rankin Scale (MRS) to assess the patients' disability, along with their sociodemographic details. Results: In this study of 76 stroke survivors, there were more male patients than women. Mean age was 55years. It was observed that 71% stroke survivors had normal cognitive assessment using MMSE. Mean score of SS-QOL was 131 hence majority had poor quality of life. Only 2% had severe impairment on MMSE and on further analysis, it was found that they had grade 5 MRS for disability, belonged to rural area, were from a nuclear type of family and had education up to higher secondary. Conclusion: Stroke has proven to have psychosocial effect on patients in terms of poor quality of life. Since functional status was the primary determinant of QoL, it has been hypothesised that increasing physical function may aid to improve QoL for stroke patients. It is imperative that more research be done on treatment and rehabilitation to improve the poor quality of life so that structured and focused interventions may be developed by policy makers.