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Spectroscopic Investigations of Porphyrin-TiO<sub>2</sub> Nanoparticles Complexes
oleh: Andra Dinache, Simona Nistorescu, Tatiana Tozar, Adriana Smarandache, Mihai Boni, Petronela Prepelita, Angela Staicu
Format: | Article |
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Diterbitkan: | MDPI AG 2022-12-01 |
Deskripsi
This study presents the spectral characterization of TiO<sub>2</sub> nanoparticles (NPs) functionalized with three porphyrin derivatives: 5,10,15,20-(Tetra-4-aminophenyl) porphyrin (TAPP), 5,10,15,20-(Tetra-4-methoxyphenyl) porphyrin (TMPP), and 5,10,15,20-(Tetra-4-carboxyphenyl) porphyrin (TCPP). UV-Vis absorption and Fourier transform infrared spectroscopy–attenuated total reflection (FTIR-ATR) spectroscopic studies of these porphyrins and their complexes with TiO<sub>2</sub> NPs were performed. In addition, the efficiency of singlet oxygen generation, the key species in photodynamic therapy, was investigated. UV-Vis absorption spectra of the NPs complexes showed the characteristic bands of porphyrins. These allowed us to determine the loaded porphyrins on TiO<sub>2</sub> NPs functionalized with porphyrins. FTIR-ATR revealed the formation of porphyrin-TiO<sub>2</sub> complexes, suggesting that porphyrin adsorption on TiO<sub>2</sub> may involve the pyrroles in the porphyrin ring, or the radicals of the porphyrin derivative. The quantum yield for singlet oxygen generation by the studied porphyrin complexes with TiO<sub>2</sub> was higher compared to bare porphyrins for TAPP and TMPP, while for the TCPP-TiO<sub>2</sub> NPs complex, a decrease was observed, but still maintained a good efficiency. The TiO<sub>2</sub> NPs conjugates can be promising candidates to be tested in photodynamic therapy in vitro assays.