TEIPP peptides: exploration of unTAPped cancer antigens
oleh: Koen A. Marijt, Sjoerd H. Van Der Burg, Thorbald van Hall
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2019-08-01 |
Deskripsi
The intracellular peptide pump TAP feeds antigenic peptides for loading onto HLA class I molecules, and its down-modulation is a frequent immune evasion mechanism in human cancers. Two recent papers describe which ‘hidden‘ antigens we might exploit to target these escaped cancer variants by CD8 T cells. These unTAPped peptides are now ready for clinical testing.