Optimization of Two Steps in Scale-Up Synthesis of Nannocystin A
oleh: Tingrong Zhang, Shaojie Miao, Mingxiao Zhang, Wenjie Liu, Liang Wang, Yue Chen
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2021-03-01 |
Deskripsi
We have accomplished a 10-step (longest linear) total synthesis of nannocystin A on a four hundred milligram scale. The previously reported Kobayashi vinylogous Mukaiyama aldol reaction to connect C4 and C5 was unreproducible during the scaling up process. A more convenient and cost-efficient Keck asymmetric vinylogous aldol reaction was employed to improve this transformation.