Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy
oleh: Seong Beom An, Bo-Gie Yang, Gyeonghui Jang, Do-Yeon Kim, Jiyoung Kim, Sung-Man Oh, Nahyun Oh, Sanghee Lee, Ji-Yeong Moon, Jeong-Ah Kim, Ji-Hyun Kim, Yoo-Jeong Song, Hye-Won Hyun, Jisoo Kim, Kyungwha Lee, Dajeong Lee, Min-Jung Kwak, Byung Kwon Kim, Young-Kyu Park, Chun-Pyo Hong, Jung Hwan Kim, Hye Seong Lim, Min Sook Ryu, Hyun-Tak Jin, Seung-Woo Lee, Yoon-Seok Chang, Hae-Sim Park, Young Chul Sung, Myoung Ho Jang
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-09-01 |
Deskripsi
IgE is a critical component of the allergic response and therapeutic targeting can alleviate symptomology. Here the authors propose the combined use of Bifidobacterium longum and a FcεRIα extracellular domain linked to a IgD/IgG4 hybrid Fc domain fusion protein called IgETRAP and show reduction of mast cell and IgE levels in models of food allergy.