Synthesis, Crystal Structure and Anti-Leukemic Activity of (<i>E</i>)-Pyrrolo[1,2-<i>a</i>]quinoxalin-4-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
oleh: Jean Guillon, Solène Savrimoutou, Sandra Albenque-Rubio, Noël Pinaud, Nina Fillová, Stéphane Moreau, Virginie Baylot, Vanessa Desplat
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2023-07-01 |
Deskripsi
(<i>E</i>)-Pyrrolo[1,2-<i>a</i>]quinoxalin-4-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one was designed then synthesized using a multi-step pathway starting from commercially available 2-nitroaniline. Structure characterization of this original substituted pyrrolo[1,2-<i>a</i>]quinoxaline compound was achieved by using FT-IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, X-Ray and HRMS spectral analysis. This new pyrroloquinoxaline shows interesting cytotoxic potential against different human leukemia cell lines (MV4-11, K562, MOLM14 and Jurkat cells).