Assessing the presence of oligoclonal IgM bands as a prognostic biomarker of cognitive decline in the early stages of multiple sclerosis
oleh: Clàudia Coll‐Martinez, Ester Quintana, Judit Salavedra‐Pont, Maria Buxó, Marina González‐del‐Rio, Immaculada Gómez, María Muñoz‐San Martín, Luisa María Villar, Gary Álvarez‐Bravo, René Robles‐Cedeño, Lluís Ramió‐Torrentà, Jordi Gich
| Format: | Article |
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| Diterbitkan: | Wiley 2021-12-01 |
Deskripsi
Abstract Background An association has been found between the presence of lipid‐specific oligoclonal IgM bands (LS‐OCMB) in cerebrospinal fluid and a more severe clinical multiple sclerosis course. Objective To investigate lipid‐specific oligoclonal IgM bands as a prognostic biomarker of cognitive impairment in the early stages of multiple sclerosis. Methods Forty‐four patients underwent neuropsychological assessment at baseline and 4 years. Cognitive performance at follow‐up was compared adjusting by age, education, anxiety–depression, and baseline performance. Results LS‐OCMB+ patients only performed worse for Long‐Term Storage in the Selective Reminding Test (p = .018). Conclusion There are no remarkable cognitive differences between LS‐OCMB– and LS‐OCMB+ patients in the early stages of MS.