Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy
oleh: Zhao Ma, Jin Li, Kai Lin, Mythili Ramachandran, Dalin Zhang, Megan Showalter, Cristabelle De Souza, Aaron Lindstrom, Lucas N. Solano, Bei Jia, Shiro Urayama, Yuyou Duan, Oliver Fiehn, Tzu-yin Lin, Minyong Li, Yuanpei Li
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-09-01 |
Deskripsi
Integration of the unique advantages of the fields of drug discovery and drug delivery is invaluable for the advancement of drug development. Here, the authors generate single-drug nanoparticles by hybridising lysomotropic detergents and the bisaminoquinoline-based autophagy inhibitor, and show their therapeutic potential as autophagy-inhibition based combination therapy.