Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance
oleh: Yufan Zhou, Diana L. Gerrard, Junbai Wang, Tian Li, Yini Yang, Andrew J. Fritz, Mahitha Rajendran, Xiaoyong Fu, Gary Stein, Rachel Schiff, Shili Lin, Seth Frietze, Victor X. Jin
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-04-01 |
Deskripsi
In breast cancer, the 3D architecture of the genome can impact gene regulation. Here, the authors use tethered chromatin conformation profiling to investigate 3D chromatin structure in models of hormone-induced breast cancer and endocrine resistance, finding dynamic temporal reorganisation.