Envelope-specific B-cell populations in African green monkeys chronically infected with simian immunodeficiency virus
oleh: Ruijun Zhang, David R. Martinez, Quang N. Nguyen, Justin Pollara, Trina Arifin, Christina Stolarchuk, Andrew Foulger, Josh D. Amos, Robert Parks, Jonathon E. Himes, Minyue Wang, Regina W. Edwards, Ashley M. Trama, Nathan Vandergrift, Lisa Colvin, Ken Dewar, Nikoleta Juretic, Jessica Wasserscheid, Guido Ferrari, Hua-Xin Liao, Sallie R. Permar
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-07-01 |
Deskripsi
Infection of African green monkeys with simian immunodeficiency virus is a potential model for HIV vaccine development. Here, Zhang et al. catalogue the immunoglobulin loci present in the genome of these animals, and experimentally study their B-cell response to the viral envelope protein.