Robust derivation of transplantable dopamine neurons from human pluripotent stem cells by timed retinoic acid delivery
oleh: Zhanna Alekseenko, José M. Dias, Andrew F. Adler, Mariya Kozhevnikova, Josina Anna van Lunteren, Sara Nolbrant, Ashwini Jeggari, Svitlana Vasylovska, Takashi Yoshitake, Jan Kehr, Marie Carlén, Andrey Alexeyenko, Malin Parmar, Johan Ericson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-06-01 |
Deskripsi
Stem cell based replacement therapies could provide a treatment for Parkinson’s disease. Here the authors outline a retinoic acid-based approach for robust derivation of dopamine neurons from stem cells that restore motor deficits in parkinsonian rats.