The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing
oleh: Christopher Bruhn, Arta Ajazi, Elisa Ferrari, Michael Charles Lanz, Renaud Batrin, Ramveer Choudhary, Adhish Walvekar, Sunil Laxman, Maria Pia Longhese, Emmanuelle Fabre, Marcus Bustamente Smolka, Marco Foiani
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-08-01 |
Deskripsi
The relationship between DNA damage response (DDR) and regulation of the tolerance to glucose restriction is currently unclear. Here the authors reveal that maintaining a physiological level of histones by Rad53-Spt21 is necessary for glucose tolerance via multiple parallel pathways, including derepression of subtelomeric genes and acetyl-coA regulation by histone acetylation.