High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS

oleh: Andrew L. Hook, John Hogwood, Elaine Gray, Barbara Mulloy, Catherine L. R. Merry

Format: Article
Diterbitkan: Nature Portfolio 2021-05-01

Deskripsi

Glycosaminoglycans are an important class of carbohydrates, but pose substantial analytical challenges. Here ToF-SIMS combined with multivariate analysis distinguishes six classes of glycosaminoglycans, including distinguishing heparin samples from different animal sources at a sensitivity as low as 0.001 wt%