Find in Library
Search millions of books, articles, and more
Indexed Open Access Databases
Acute and sub-acute toxicity study of hydro-alcoholic leaves extract of Reinwardtia indica in rats
oleh: Prabhat Upadhyay, Rashmi Shukla, Sunil Kumar Mishra
Format: | Article |
---|---|
Diterbitkan: | Elsevier 2019-03-01 |
Deskripsi
The present study was to assess the toxicity of hydro alcoholic leaves extract of Reinwardtia indica in Charles foster rats through an acute and sub-acute study. In the acute study, rats were treated orally with single dose and for sub-acute study different doses were given orally for 28 consecutive days. At the dose of 2000 mg/kg satellite group was also used for 6 weeks as per OECD guidelines-407. General behavioral parameters were assessed in acute toxicity and found no mortality or exterior signs of toxicity. While in the sub-acute study; biochemical, hematological and histopathology along with the body weight, food, and water consumptions parameters were screened in the animals after 14 & 28 days. The study reveals the insignificant (P < 0.05) change in treated group in comparison to the control. The hydroalcoholic leaves extract of Reinwardtia indica was found non-toxic up to 5000 mg/kg in acute study whereas up to 2000 mg/kg dose level in the sub-acute study.