Muscle progenitor specification and myogenic differentiation are associated with changes in chromatin topology
oleh: Nan Zhang, Julen Mendieta-Esteban, Alessandro Magli, Karin C. Lilja, Rita C. R. Perlingeiro, Marc A. Marti-Renom, Aristotelis Tsirigos, Brian David Dynlacht
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-12-01 |
Deskripsi
Chromatin structure and topology play important roles in the regulation of gene expression. Here the authors study the spatio-temporal re-organization of promoter-enhancer interactions in pluripotent ES and skeletal muscle stem cells and the corresponding impact on gene expression as a consequence of myogenic commitment and differentiation.